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Skincare Ingredients Guide : Products That Shouldn't Be Used Together

Achieving glowing, healthy skin requires knowing not only which products to use but also how to use them. While some ingredients work beautifully together, others can clash, causing irritation, dryness, or even rendering each other ineffective. Below is a guide to skincare combinations that are best avoided to keep your routine effective and safe.

skincare products to not mix

Skincare Ingredients Guide

Ingredients to Avoid Using Together: Skincare Ingredients Guide

1. Retinol and Alpha Hydroxy Acids (AHAs)

  • Why? Both retinol and AHAs (like glycolic acid or lactic acid) are potent exfoliants. Combining them can over-exfoliate your skin, leading to redness, peeling, and heightened sensitivity to sunlight.

  • What to do instead: Use them on alternate nights or apply AHAs in the morning and retinol at night, always followed by sunscreen during the day.

2. Vitamin C and Retinol

  • Why? Vitamin C and retinol have different pH requirements to function optimally. Using them together may reduce their effectiveness and cause irritation.

  • What to do instead: Apply vitamin C in the morning for antioxidant protection and retinol at night to boost collagen production.

3. AHAs or BHAs and Vitamin C

  • Why? AHAs (like glycolic acid) and BHAs (like salicylic acid) are acids, as is vitamin C (ascorbic acid). Layering these can overwhelm the skin, leading to irritation and sensitivity.

  • What to do instead: Use vitamin C in the morning and AHAs/BHAs at night to avoid overloading your skin.

4. Retinol and Benzoyl Peroxide

  • Why? These two powerhouse ingredients can cancel each other out when applied together. Plus, both can be drying and irritating if combined.

  • What to do instead: Use benzoyl peroxide as a spot treatment in the morning and retinol in the evening.

5. Niacinamide and Vitamin C (Controversial)

  • Why? While modern formulations may make this pairing less problematic, older formulations of vitamin C and niacinamide can react to form niacin, which may cause redness and irritation.

  • What to do instead: If you have sensitive skin, use vitamin C in the morning and niacinamide in the evening.

6. AHAs/BHAs and Physical Exfoliants

  • Why? Using a chemical exfoliant like AHAs or BHAs alongside a scrub can lead to over-exfoliation, damaging the skin barrier and causing sensitivity.

  • What to do instead: Choose one exfoliation method at a time—chemical or physical—and use it no more than 2–3 times a week.

7. Retinol and AHAs/BHAs with Harsh Cleansers

  • Why? Harsh cleansers strip the skin’s natural oils, and pairing them with potent actives can lead to irritation and dryness.

  • What to do instead: Use a gentle, hydrating cleanser when using active ingredients.

8. Vitamin C and Copper Peptides

  • Why? Copper peptides can oxidize vitamin C, reducing its effectiveness and potentially causing skin irritation.

  • What to do instead: Use vitamin C in the morning and copper peptides in the evening.

9. AHAs/BHAs and Hydrocortisone Cream

  • Why? Hydrocortisone is often used to calm irritated skin, but pairing it with exfoliating acids can worsen irritation instead of soothing it.

  • What to do instead: Use hydrocortisone only when your skin needs calming, and avoid exfoliants during this time.

How to Safely Introduce New Ingredients

  1. Patch Test First: Apply a small amount of the product on your wrist or behind your ear and wait 24 hours to check for any adverse reactions.

  2. Start Slowly: Introduce one new product at a time to monitor how your skin reacts.

  3. Use Sunscreen: Many active ingredients increase photosensitivity, so sunscreen is non-negotiable.

  4. Consult a Dermatologist: If you’re unsure about combining certain products, seek professional advice.


Understanding the chemistry behind skincare ingredients can save your skin from unnecessary irritation and help you get the most out of your routine. Avoid these common pitfalls, and you’ll be well on your way to achieving a radiant complexion!


Beauthic Talk LIVA

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